| 1 seed vs 16 seed |
| Kansas (B12) vs Holy Cross(Pat)/FDU(NEC) |
| North Carolina (ACC) vs Southern(SWAC)/Florida GC(Asun) |
| Michigan State (B1G) vs Austin Peay (OVC) |
| Oregon (P12) vs Hampton(MEAC) |
| 2 seed vs 15 seed |
| Virginia vs UNC-Ashville (Bsouth) |
| Villanova vs Weber St (Bsky) |
| Oklahoma vs CS-Bakersfield (WAC) |
| Miami vs UWGB (Horizon) |
| 3 seed vs 14 seed |
| Kentucky (SEC) vs Hawaii (Bwest) |
| Xavier vs SFA (Sland) |
| West Virginia vs UNC-Wilmington (Colonial) |
| Utah vs Buffalo (MAC) |
| 4 seed vs 13 seed |
| Purdue vs Fresno St (Mwest) |
| Texas A&M vs MTST (Cusa) |
| Maryland vs Iona (MAAC) |
| Iowa State vs Yale (Ivy) |
| 5 seed vs 12 seed |
| Indiana vs Stony Brook (Aest) |
| Arizona vs S.Dakota St (Summit) |
| Duke vs Chattanooga (SoCon) |
| California vs UALR (Sbelt) |
| 6 seed vs 11 seed |
| Notre Dame vs Northern Iowa (Mvalley) |
| Dayton vs Syacuse/Monmouth |
| Seton Hall (Beast) vs San Diego St/Temple |
| Texas vs Wichita St |
| 7 seed vs 10 seed |
| Iowa vs Butler |
| Texas Tech vs Gonzaga (WCC) |
| Baylor vs Pittsburgh |
| Wisconsin vs Cincinnati |
| 8 seed vs 9 seed |
| St. Joseph's vs Connecticut (AAC) |
| Providence vs Oregon State |
| Colorado vs VCU (A10) |
| USC vs St. Bonavanture |
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