| 1 seed vs 16 seed |
| Indiana (B1G) vs Southern(SWAC)/C.Southern(Bsouth) |
| Gonzaga (WCC) vs NorfolkSt(MEAC)/Robert Morris(NEC) |
| Kansas (B12) vs Mercer (Asun) |
| Miami (ACC) vs Northeastern (CAA) |
| 2 seed vs 15 seed |
| Duke vs Niagara (MAAC) |
| Louisville vs Montana (Bsky) |
| Michigan State vs Long Beach State (Bwest) |
| Florida (SEC) vs Harvard (Ivy) |
| 3 seed vs 14 seed |
| Georgetown (Beast) vs Valparasio (Horizon) |
| Michigan vs Stony Brook (Aeast) |
| New Mexico (MWC) vs Davidson (SoCon) |
| Syracuse vs Northwestern St (Sland) |
| 4 seed vs 13 seed |
| Arizona (Pac12) vs Bucknell (Patriot) |
| Kansas State vs South Dakota State (Summit) |
| Wisconsin vs Louisiana Tech (WAC) |
| Oklahoma State vs Belmont (OVC) |
| 5 seed vs 12 seed |
| Marquette vs Mid Tenn State (Sbelt) |
| Ohio State vs Kentucky/Villanova |
| Pittsburgh vs Mississippi/Temple |
| Butler vs Iowa State |
| 6 seed vs 11 seed |
| Notre Dame vs California |
| UNLV vs Akron (MAC) |
| St. Louis (A10) vs St. Mary's |
| Colorado State vs LaSalle |
| 7 seed vs 10 seed |
| UCLA vs Cinncinati |
| Oregon vs Virginia |
| N. Carolina State vs Oklahoma |
| Memphis (Cusa) vs Colorado |
| 8 seed vs 9 seed |
| North Carolina vs Minnesota |
| San Diego State vs Creighton |
| Missouri vs Wichita State (MVC) |
| VCU vs Illinois |
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