| 1 seed vs 16 seed |
| Duke vs Southern(SWAC)/Liberty(Bsouth) |
| Indiana (B1G) vs Morgan St(MEAC)/Long Island(NEC) |
| Gonzaga (WCC) vs James Madison (CAA) |
| Louisville vs W. Kentucky (Sbelt) |
| 2 seed vs 15 seed |
| Georgetown (Beast) vs Long Beach State (Bwest) |
| Miami (ACC) vs Vermont (Aeast) |
| Michigan State vs Iona (MAAC) |
| Kansas (B12) vs Florida Gulf Coast (Asun) |
| 3 seed vs 14 seed |
| Michigan vs Montana (Bsky) |
| Ohio State vs Harvard (Ivy) |
| Florida (SEC) vs Stephen F Auston (Sland) |
| New Mexico (MWC) vs South Dakota State (Summit) |
| 4 seed vs 13 seed |
| Oklahoma State vs New Mexico State (WAC) |
| Arizona vs Davidson (SoCon) |
| Kansas State vs Valparasio (Horizon) |
| Syracuse vs Bucknell (Patriot) |
| 5 seed vs 12 seed |
| St. Louis (A10) vs Akron (MAC) |
| Marquette vs LaSalle/Mid Tenn St |
| Butler vs Kentucky |
| UCLA (P12) vs Villanova/Tennessee |
| 6 seed vs 11 seed |
| Wisconsin vs California |
| UNLV vs Oklahoma |
| Notre Dame vs Temple |
| Pittsburgh vs Belmont (OVC) |
| 7 seed vs 10 seed |
| Colorado State vs Minnesota |
| VCU vs Colorado |
| Creighton (MVC) vs Cincinnati |
| Memphis (Cusa) vs St. Mary's |
| 8 seed vs 9 seed |
| North Carolina vs Iowa State |
| N. Carolina State vs Oregon |
| Illinois vs Wichita State |
| Missouri vs San Diego State |
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