| 1 seed vs 16 seed |
| Indiana (B1G) vs Southern(SWAC)/High Point(Bsouth) |
| Miami (ACC) vs NorfolkSt(MEAC)/Robert Morris(NEC) |
| Florida (SEC) vs Mercer (Asun) |
| Gonzaga (WCC) vs Niagara (MAAC) |
| 2 seed vs 15 seed |
| Michigan vs Northeastern (CAA) |
| Kansas (B12) vs Montana (Bsky) |
| Michigan State vs Long Beach State (Bwest) |
| Duke vs Harvard (Ivy) |
| 3 seed vs 14 seed |
| Louisville vs Valparasio (Horizon) |
| Arizona vs Stony Brook (Aeast) |
| Syracuse (Beast) vs Davidson (SoCon) |
| New Mexico (MWC) vs Stephen F. Austin (Sland) |
| 4 seed vs 13 seed |
| Georgetown vs Bucknell (Patriot) |
| Kansas State vs South Dakota State (Summit) |
| Marquette vs Akron (MAC) |
| Oklahoma State vs Louisiana Tech (WAC) |
| 5 seed vs 12 seed |
| Butler vs Belmont (OVC) |
| Wisconsin vs Villanova/Temple |
| Pittsburgh vs St. Mary's/Maryland |
| Ohio State vs California |
| 6 seed vs 11 seed |
| Oregon (Pac12) vs Mid Tenn State (Sbelt) |
| Colorado State vs Baylor |
| N. Carolina State vs Oklahoma |
| UCLA vs LaSalle |
| 7 seed vs 10 seed |
| VCU (A10) vs Iowa State |
| Creighton vs Mississippi |
| Illinois vs St. Louis |
| Notre Dame vs North Carolina |
| 8 seed vs 9 seed |
| Cinncinati vs Colorado |
| UNLV vs Memphis (Cusa) |
| Wichita State (MVC) vs San Diego State |
| Minnesota vs Missouri |
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