| 1 seed vs 16 seed |
| Michigan vs Southern(SWAC)/UNCAshville(Bsouth) |
| Duke vs NorfolkSt(MEAC)/Bryant (NEC) |
| Florida (SEC) vs Northeastern (CAA) |
| Indiana (B1G) vs Niagara (MAAC) |
| 2 seed vs 15 seed |
| Arizona vs Florida Gulf Coast (Asun) |
| Miami (ACC) vs Montana (Bsky) |
| Kansas (B12) vs Davidson (SoCon) |
| Gonzaga (WCC) vs Long Beach State (Bwest) |
| 3 seed vs 14 seed |
| Syracuse (Beast) vs Valparasio (Horizon) |
| Louisville vs Stony Brook (Aeast) |
| Michigan State vs Harvard (Ivy) |
| Butler (A10) vs Stephen F. Austin (Sland) |
| 4 seed vs 13 seed |
| Ohio State vs Lehigh (Patriot) |
| Minnesota vs South Dakota State (Summit) |
| New Mexico (MWC) vs Akron (MAC) |
| Cinncinati vs Louisiana Tech (WAC) |
| 5 seed vs 12 seed |
| Marquette vs Temple/St. John's |
| Kansas State vs St.Louis/Illinois |
| Georgetown vs St. Mary's |
| Pittsburgh vs Belmont (OVC) |
| 6 seed vs 11 seed |
| Creighton (MVC) vs Baylor |
| Oregon (Pac12) vs Mid Tenn State (Sbelt) |
| UCLA vs LaSalle |
| VCU vs Indiana State |
| 7 seed vs 10 seed |
| Notre Dame vs Oklahoma |
| Oklahoma State vs Iowa State |
| Wisconsin vs Memphis (Cusa) |
| San Diego State vs Colorado |
| 8 seed vs 9 seed |
| Missouri vs Colorado State |
| N. Carolina State vs Mississippi |
| North Carolina vs Kentucky |
| UNLV vs Wichita State |
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